Kevin Weil

RT Andrej Karpathy I am unreasonably excited about self-driving. It will be the first technology in many decades to visibly terraform outdoor physical spaces and way of life. Less parked cars. Less parking lots. Much greater safety for people in and out of cars. Less noise pollution. More space reclaimed for humans. Human brain cycles and attention capital freed up from “lane following” to other pursuits. Cheaper, faster, programmable delivery of physical items and goods. It won’t happen overnight but there will be the era before and the era after.

RT Crémieux Paul Erdős won a bet by proving he wasn't addicted to amphetamines. But he got nothing done: "You've showed me I'm not an addict... You've set mathematics back a month."

RT Sebastien Bubeck Looks like a pretty long CoTFermat's Library: Andrew Wiles on the morning he discovered how to fix his proof of Fermat's Last Theorem Link: https://x.com/fermatslibrary/status/1986131120623145125

Just imagine where we'll be a year from now...Ethan Mollick: A year ago, I would not have expected the first academic field to seem to reach a consensus that AIs will accelerate research (which is not the same thing as autonomous research) would be math But that appears to be happening based on math professors in my feed and elsewhere. Link: https://x.com/emollick/status/1984388281061282081

Would love to hear more details if you're comfortable sharing, @wtgowers!Timothy Gowers @wtgowers: I crossed an interesting threshold yesterday, which I think many other mathematicians have been crossing recently as well. In the middle of trying to prove a result, I identified a statement that looked true and that would, if true, be useful to me. 1/3 Link: https://x.com/wtgowers/status/1984340182351634571

100% agree with @ErnestRyu here—this is an exciting time in mathematics, and in science more broadly.Ernest Ryu: I firmly believe we are at a watershed moment in the history of mathematics. In the coming years, using LLMs for math research will become mainstream, and so will Lean formalization, made easier by LLMs. (1/4) Link: https://x.com/ErnestRyu/status/1984033423586160889

RT Derya Unutmaz, MD Here is the story of a remarkable, independent treatment suggestion by GPT-5 Pro: repurposing a known drug for a patient with food protein–induced enterocolitis syndrome (FPIES). First, how we came to test this. My close friend, physician-scientist Dr. Oral Alpan, treated the patient described in the published report (link in the thread) for refractory allergic skin disease with the biologic dupilumab, which is approved for that indication. The patient also had FPIES, a food allergy that in his case was triggered by wheat and caused hours of cramping and watery, sometimes bloody, diarrhea. There is no approved treatment for FPIES; patients are advised to avoid trigger foods and prepare for emergencies if accidental exposure occurs. For twenty years, even a small amount of wheat set off the same cascade a few hours later, followed by days of recovery. After starting dupilumab for his skin condition, the patient traveled to France and accidentally ate a baguette. To his surprise, nothing happened! It was his first uneventful wheat exposure in two decades! On return, Dr. Alpan hypothesized that dupilumab might be responsible and supervised an oral food challenge approaching 50 grams of wheat protein. Again, no reaction! When an insurance interruption forced a pause in medication, the old symptoms returned; restarting it restored tolerance. In the peer-reviewed paper published today, Dr. Alpan and his team describe seven additional patients, ages 2 to 58, who responded to dupilumab for their FPIES condition. While this is not definitive proof and represents an observational case series, the findings suggest that dupilumab could be a potential treatment for FPIES. Dr. Alpan intends to contact Regeneron, the manufacturer, to pursue clinical studies hopefully toward FDA approval for this disease. About two months ago, as he had just submitted the paper on this case, Dr. Alpan told me this story. Until today’s publication there were no reports in t...